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Volume 1

eGastroenterology is an open-access and peer-reviewed journal launched by a group of top gastroenterologists and hepatologists. It is dedicated to both clinical and basic research in gastroenterology, encompassing hepatology, pancreatology, esophagology, gastrointestinal surgery, and related sciences. The "e" in the journal's name symbolizes its commitment to fostering an "emerging," "elite," and "enlightening" vision within the field. The cover image was designed by M. Gao. Correspondence: Menghan Gao (egastro@jlu.edu.cn)
The cover image shows multiplex immunofluorescence staining of liver tissue 48 hours after concanavalin A–induced liver injury. CD31+ liver sinusoidal endothelial cells (LSECs, Magenta) were damaged in the necrotic area. Monocyte-derived macrophages (MoMFs, Cyan) formed a "ring-like" structure facing necrotic areas, which induced Sox9 expression (Red) on hepatocytes (HNF4α+, Green) around the necrotic area. These Sox9+HNF4α+ hepatocytes were resistant to cell death and prevented further liver damage. The cover image was obtained by B. Gao and D. Feng Correspondence: Bin Gao (bgao@mail.nih.gov)

Volume 2

The cover image displays a group of electron microscopy images of mitochondria-lysosome-related organelles (MLRO), which are electron dense organelles that have either a single or double membrane. The central image shows red-COX8 fragmented mitochondria that are colocalized with lysosome (LAMP1 positive, blue). Ma et al find that the formation of MLRO may lead to hepatocyte dedifferentiation, which may be relevant to various chronic liver disease including alcohol-associated liver disease and metabolic dysfunction associated liver disease. The cover image was designed by W.X. Ding and X. Ma. Correspondence: Wen-Xing Ding (wxding@kumc.edu)
The image portrays the diverse microbiota in the human colon, and the interaction between these microorganisms and prebiotics consumed by the host. It contrasts a healthy microbial community with the disrupted, dysbiotic state observed in inflammatory bowel disease (IBD), which negatively impacts inflammation and disease symptoms. Our review presents the potential of different prebiotics in improving microbial and disease outcomes, based on findings from animal colitis models and human IBD studies, highlighting the impact of prebiotic selection on IBD outcomes. The cover image was designed by A. Ariaee. Correspondence: P. Joyce (paul.joyce@unisa.edu.au)
The cover image showcases advanced endoscopic technologies, including virtual chromoendoscopy (1st image), Cellvizio® confocal laser endomicroscopy (2nd image), Olympus® high-magnification endocytoscopy (3rd image), and the Red density-Pentax algorithm (4th image). These tools, integrated by artificial intelligence, promise to standardise assessment of remission and healing in Inflammatory Bowel Disease, enhancing prediction of therapy responses and outcomes. The cover image was designed by M. Iacucci Correspondence: Marietta Iacucci MD, PhD, FASGE, FRCPE, AGAF (miacucci@ucc.ie)