Table 2

Performance of SSM in the diagnosis of CSPH and OVs

Author and yearStudy typeAetiologyPopulationElastography technique (Machine)OutcomeCut-off valuesPerformanceAUROC
Colecchia et al 201246 ProspectiveHCV100TE (FibroScan)CSPHRule-in: ≥52.2 kPa
Rule-out: < 40 kPa
SE: 76.9%; Sp: 97.1%
SE: 98.5%; Sp: 74.3%
0.941
Takuma et al 201347 ProspectiveMixed (HBV, HCV, alcohol, other)62ARFI
(Siemens Acuson S2000)
CSPH3.1 m/sAccuracy: 80.0%; SE: 97.1%; Sp: 57.7%; PPV:75.0%; NPV: 93.7%0.943
Zykus et al 201548 ProspectiveMixed (HCV, Alcoholic liver disease, Cryptogenic liver disease, other)107TE (FibroScan)CSPH50.7 kPaAccuracy: 77.7%; SE: 78.1%; Sp: 77.1%; PPV:86.2%; NPV: 65.8%0.846
Stefanescu et al 202036 ProspectiveMixed (HBV, HCV, alcohol, other)260TE
(FibroScan 630 Expert:SSM@100 Hz)
CSPH34.15 kPaAccuracy: 85%0.811
Stefanescu et al 201113 ProspectiveMixed (HCV, alcohol)191TE (FibroScan)OVs46.4 kPaAccuracy: 80.45%; SE: 83.56%; Sp: 71.43%; PPV:93.8%; NPV: 45.5%0.781
Colecchia et al 201246 ProspectiveHCV100TE (FibroScan)OVsRule-in: ≥55.0 kPa
Rule-out: < 41.3 kPa
SE: 71.7%; Sp: 95.7%
SE: 98.1%; Sp: 66.0%
0.966
Sharma et al 201349 ProspectiveMixed (HBV, HCV, alcohol, cryptogenic)174TE (FibroScan)OVs40.8 kPaSE: 94%; Sp: 76%; PPV:91%; NPV: 84%0.898
Giuffrè et al 202045 ProspectiveMixed (Viral, Alcohol abuse, others)210p-SWE
(Philips Affiniti 70)
OVs31 kPaAccuracy: 76%; SE: 100%; Sp: 60%; PPV:62%; NPV: 100%N/A
Mnif et al 202143 ProspectiveHBV84TE (FibroScan)OVs33.1 kPaSE: 72.2%; Sp: 77.1%; PPV:51%; NPV: 63%0.795
Hirooka et al 202144 RetrospectiveMixed (HBV, HCV)349TE (FibroScan)HRV45 kPaSE: 92.1%; Sp: 64.6%; PPV:47.3%; NPV: 95.9%0.854
Tanaka et al 20216 ProspectiveMixed (HBV, HCV)292TE (FibroScan)HRV46.4 kPaAccuracy: 80.45%; SE: 92.3%; Sp: 72.4%; PPV:53.3%; NPV: 74.5%0.88
Nagai et al 202242 ProspectiveMixed (HBV, HCV, alcohol, NAFLD, IPH, other)123TE
(FibroScan 630 Expert:SSM@100 Hz)
HRV43.8 kPaSE: 93.3%; Sp: 82.0%; PPV:70.0%; NPV: 96.4%0.941
  • ARFI, acoustic radiation force impulse; AUROC, area under the receiver operating characteristic curve; CSPH, clinically significant portal hypertension; HBV, hepatitis B virus; HCV, hepatitis C virus; HRV, high-risk varices; IPH, idiopathic portal hypertension; NAFLD, non‐alcoholic fatty liver disease; NPV, negative predictive value; OVs, oesophageal varices; PPV, positive predictive value; p-SWE, point shear wave elastography; SE, sensitivity; Sp, specificity; SSM, spleen stiffness measurement; TE, transient elastography.